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New tools allow rapid ID of CRISPR-Cas system PAMs

New tools allow rapid ID of CRISPR-Cas system PAMs

CRISPR-Cas systems are widely heralded as a new generation of genetic tools. But development of these tools requires researchers to identify the protospacer-adjacent motifs (PAMs) that unlock each system’s functionality. A new set of techniques expedites PAM identification—and early testing finds that many CRISPR-Cas systems actually have multiple PAMs of varying strength. CRISPR-Cas systems protect […]